The use of alpha-casozepine (Lactium®) and vitamin B6 in clinical practice (literature review)

The literature data on the use of alpha-casozepine and its combination with vitamin B6 in clinical practice are summarized. It has been established that the properties of alpha-casozepine are similar to those of the benzodiazepine family, except for such concomitant side effects as addiction or sedation, such as addiction or sedation, so recently alpha-casozepine has been used more often as a dietary supplement to improve sleep and for the treatment of stress disorders. The anxiolytic effects of alpha-casozepine have been confirmed in many studies over the past 20 years.
It has been established that alpha-casozepine affects sleep by modulating its architecture, but has virtually no sedative effect, which makes it similar to melatonin. The effect of alpha-casozepine on sleep is associated with GABA receptors. It has been found that during the transport of the peptide across the blood-brain barrier, the C-terminal residue of tryptophan, a precursor of serotonin, which is an important neurotransmitter in the regulation of mood and satiety, is released. Alpha-casozepine has been shown to directly modulate GABA receptors, including in hypothalamic neurons.
According to clinical trials, alpha-casozepine has a positive effect on both physical and psychological symptoms of anxiety. It has been shown that the use of alpha-casozepine promotes faster recovery from a stress response, which is manifested by lower blood pressure and heart rate during the relaxation period (after stress) compared to the rest period (before stress induction).

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